Motor cortex disinhibition in Alzheimer's disease

被引:93
作者
Liepert, J
Bär, KJ
Meske, U
Weiller, C
机构
[1] Univ Jena, Dept Neurol, D-6900 Jena, Germany
[2] Univ Jena, Dept Psychiat, D-6900 Jena, Germany
关键词
intracortical inhibition; intracortical facilitation; dementia; Alzheimer's disease; transcranial magnetic stimulation; donepezil;
D O I
10.1016/S1388-2457(01)00554-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: To explore subclinical disturbances in the motor cortex of patients with Alzheimer's disease (AD). Methods: We used transcranial magnetic stimulation in a paired pulse technique to test intracortical inhibition (ICI) and intracortical facilitation in mildly to moderately demented AD patients with a normal neurological examination. Patients were studied before and during treatment with the cholinesterase inhibitor donepezil. Results: AD patients had a reduced ICI compared to an age-matched control group. The amount of disinhibition correlated with the severity of dementia. Treatment with 10 mg donepezil daily was associated with an increase of ICL Conclusions: The subclinical motor cortex disinhibition in AD patients indicates a functional disturbance, and is probably associated with a cholinergic deficit. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:1436 / 1441
页数:6
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