Recombinant vaccines for hepatitis E

被引：67

作者：

Emerson, SU

Purcell, RH

机构：

[1] NIAID, Mol Hepatitis Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Hepatitis Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 10期

关键词：

D O I：

10.1016/S1471-4914(01)02106-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis E virus causes epidemics of acute hepatitis in many developing countries. It infrequently causes disease in developed countries, but avirulent strains might circulate. Some evidence suggests that hepatitis E might be a zoonosis. There is probably only a single serotype. A candidate vaccine consisting of baculovirus-expressed recombinant capsid protein protected macaques from hepatitis E - it passed phase I clinical trials and is currently scheduled for phase II/III clinical trials.

引用

页码：462 / 466

页数：5

共 57 条

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