DNA-photocleavage agents

被引：43

作者：

Da Ros, T

Spalluto, G

Boutorine, AS

Bensasson, RV

Prato, M

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Museum Natl Hist Nat, CNRS UMR 8646, INSERM U 201, Biophys Lab, F-75231 Paris 05, France

来源：

CURRENT PHARMACEUTICAL DESIGN | 2001年 / 7卷 / 17期

关键词：

D O I：

10.2174/1381612013397140

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review describes recent advances in the development of DNA-photocleavage agents. Major mechanisms of photosensitized DNA photocleavage are presented and the most popular categories of compounds are considered, which include metal complexes and many organic functional derivatives. DNA-targeted conjugates of photosensitizers are also described and discussed.

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页码：1781 / 1821

页数：41

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共 183 条

[1] Photooxidative damage of guanine in DG and DNA by the radicals derived from the α cleavage of the electronically excited carbonyl products generated in the thermolysis of alkoxymethyl-substituted dioxetanes and the photolysis of alkoxyacetones [J].

Adam, W ;

Arnold, MA ;

Saha-Möller, CR .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (02) :597-604

[2] FACILE REDUCTION OF 1,2-DIOXETANES BY THIOLS AS POTENTIAL PROTECTIVE MEASURE AGAINST PHOTOCHEMICAL DAMAGE OF CELLULAR DNA [J].

ADAM, W ;

EPE, B ;

SCHIFFMANN, D ;

VARGAS, F ;

WILD, D .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1988, 27 (03) :429-431

[3] Sequence-specific modification of guanosine in DNA by a C-60-linked deoxyoligonucleotide: Evidence for a non-singlet oxygen mechanism [J].

An, YZ ;

Chen, CHB ;

Anderson, JL ;

Sigman, DS ;

Foote, CS ;

Rubin, Y .

TETRAHEDRON, 1996, 52 (14) :5179-5189

[4] Highly selective DNA modification by ambient O2-activated Co(II)•Lys-Gly-His metallopeptides [J].

Ananias, DC ;

Long, EC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (42) :10460-10461

[5] PHOTOCYTOTOXICITY OF WATER-SOLUBLE METALLOPORPHYRIN DERIVATIVES [J].

ANDO, T ;

IRIE, K ;

KOSHIMIZU, K ;

TAKEMURA, T ;

NISHINO, H ;

IWASHIMA, A ;

TAKEDA, N ;

NAKAJIMA, S ;

SAKATA, I .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 57 (04) :629-633

[6] Peptide nucleic acid (PNA) DNA hybrid duplexes: intercalation by an internally linked anthraquinone [J].

Armitage, B ;

Koch, T ;

Frydenlund, H ;

Orum, H ;

Schuster, GB .

NUCLEIC ACIDS RESEARCH, 1998, 26 (03) :715-720

[7] Peptide nucleic acid-DNA duplexes: Long range hole migration from an internally linked anthraquinone [J].

Armitage, B ;

Ly, D ;

Koch, T ;

Frydenlund, H ;

Orum, H ;

Batz, HG ;

Schuster, GB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12320-12325

[8] Photocleavage of nucleic acids [J].

Armitage, B .

CHEMICAL REVIEWS, 1998, 98 (03) :1171-1200

[9] Anthraquinone photonucleases: A surprising role for chloride in the sequence-neutral cleavage of DNA and the footprinting of minor groove-bound ligands [J].

Armitage, B ;

Schuster, GB .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 66 (02) :164-170

[10] CATIONIC ANTHRAQUINONE DERIVATIVES AS CATALYTIC DNA PHOTONUCLEASES - MECHANISMS FOR DNA-DAMAGE AND QUINONE RECYCLING [J].

ARMITAGE, B ;

YU, CJ ;

DEVADOSS, C ;

SCHUSTER, GB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (22) :9847-9859

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