MHC class II-associated invariant chain (Ii) modulates dendritic cells-derived microvesicles (DCMV)-mediated activation of microglia

被引：18

作者：

Teo, Boon Heng Dennis ^{[1
]}

Wong, Siew Heng ^{[1
]}

机构：

[1] Natl Univ Singapore, Lab Membrane Trafficking & Immunoregulat, Yong Loo Lin Sch Med, Dept Microbiol,Immunol Program, Singapore 117597, Singapore

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 400卷 / 04期

基金：

英国医学研究理事会;

关键词：

Dendritic cells; Invariant chain; Microglia; Microvesicles; NF-KB; MULTIVESICULAR BODIES; MEMBRANE-VESICLES; MULTIPLE ROLES; EXOSOMES; CD74; INFLAMMATION; INDUCTION; INTERACTS; CNS;

D O I：

10.1016/j.bbrc.2010.08.126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dendritic cells (DC) - the sentinels of the immune system - play an important role in the maintenance of tolerance and induction of immunity. However, in autoimmune diseases, DC initiate the diseases by presenting self antigens to autoreactive T cells, causing the immune system to mount a response against the body. An example is multiple sclerosis (MS) and its corresponding animal model, experimental autoimmune encephalomyelitis (EAE). During inflammation of the central nervous system (CNS), DC are recruited to activate autoreactive T cells. Microglia - resident mononuclear phagocytes of the brain - also play a role in the pathogenesis of the disease. In this study, we demonstrated that microvesicles derived from DC (DCMV) induced the activation of NF-kappa B in microglia. Furthermore, MHC class II-associated invariant chain (Ii), also known as CD74, was specifically recruited to DCMV and interestingly, was able to enhance the DCMV-mediated activation of NF-kappa B in microglia. Thus, this study emphasizes the role of microvesicles and Ii in the communication between DC and microglia. (c) 2010 Elsevier Inc. All rights reserved.

引用

页码：673 / 678

页数：6