Synthesis of fluorinated ethyl 4-aryl-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one/thione-5-carboxylates under microwave irradiation

被引：41

作者：

Dandia, A ^{[1
]}

Saha, M ^{[1
]}

Taneja, H ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1998年 / 90卷 / 01期

关键词：

microwave irradiation; tetrahydropyrimidin-2-one/thione-5-carboxylates; Biginelli compounds;

D O I：

10.1016/S0022-1139(98)00140-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Microwaves have been found to greatly accelerate the Biginelli synthesis of fluorine containing ethyl 4-aryl-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one/thione-5-carboxylates in unsealed vessels using ethanol as energy transfer medium. Results were compared with those obtained following the classical method. The advantages obtained by the use of microwave irradiation were demonstrated. All synthesized compounds have been characterized on the basis of elemental analyses, IR, H-1 NMR and F-19 NMR spectral studies. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：17 / 21

页数：5