Sequenced reactions with samarium(II)Iodide. Tandem nucleophilic acyl substitution/ketyl-olefin coupling reactions

被引：72

作者：

Molander, GA

Harris, CR

机构：

[1] Department of Chemistry, University of Colorado, Boulder

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 17期

关键词：

D O I：

10.1021/ja952619k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Samarium(II) iodide has been employed to promote a tandem intramolecular nucleophilic acyl substitution/intramolecular ketyl-olefin coupling cyclization sequence, generating bicyclic, tricyclic, and spirocyclic ring systems in excellent yield and with high diastereoselectivity. This versatile reaction sequence allows entry to several different naturally occurring tricyclic systems containing the angular and linear triquinane framework.

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页码：4059 / 4071

页数：13

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