Granulocyte colony-stimulating factor is not protective against selective dopaminergic cell death in vitro

被引：5

作者：

Henze, C ^{[1
]}

Lescot, T ^{[1
]}

Traver, S ^{[1
]}

Salthun-Lassalle, B ^{[1
]}

Hirsch, EC ^{[1
]}

Michel, PP ^{[1
]}

Hartmann, A ^{[1
]}

机构：

[1] Hop La Pitie Salpetriere, Ctr Invest Clin, INSERM U679, F-75651 Paris, France

来源：

NEUROSCIENCE LETTERS | 2005年 / 383卷 / 1-2期

关键词：

Parkinson's disease; granulocyte colony-stimulating factor; 1-methyl-4-phenylpyridinium;

D O I：

10.1016/j.neulet.2005.03.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we evaluated the potential neuroprotective effect of granulocyte colony-stimulating factor (G-CSF), a hematopoietic growth factor in two different culture models in which dopaminergic (DA) neurons die selectively: first, in a culture model in which death of DA neurons occurs spontaneously and second, in a toxin-based paradigm, the in vitro 1-methyl-4-phenylpyridinium model of PD. In neither of the two models, a treatment with G-CSF, could prevent or halt the progressive neurodegeneration. However, we cannot rule out that G-CSF might exert neuroprotective or even deleterious effects in in vivo models of PD, based on the significant increase in the number of microglial cells observed after G-CSF treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：44 / 48

页数：5

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