Amyloid β 38, 40, and 42 species in cerebrospinal fluid:: more of the same?

被引：105

作者：

Schoonenboom, NS

Mulder, C

Van Kamp, GJ

Mehta, SP

Scheltens, P

Blankenstein, MA

Mehta, PD

机构：

[1] VU Univ, Med Ctr, Dept Neurol, NL-1081 HV Amsterdam, Netherlands

[2] VU Univ, Med Ctr, Dept Clin Chem, NL-1081 HV Amsterdam, Netherlands

[3] VU Univ, Med Ctr, Alzheimer Ctr, NL-1081 HV Amsterdam, Netherlands

[4] Inst Basic Res Dev Disabil, Div Immunol, Dept Dev Neurobiol, Staten Isl, NY USA

来源：

ANNALS OF NEUROLOGY | 2005年 / 58卷 / 01期

关键词：

D O I：

10.1002/ana.20508

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various C-terminally truncated amyloid beta peptides (A beta) are linked to Alzheimer's disease (AD) pathogenesis. Cerebrospinal fluid (CSF) concentrations of A beta 38, A beta 40, and A beta 42 were measured by enzyme-linked immunosorbent assay in 30 patients with AD and 26 control subjects. CSF A beta 42 levels was decreased in patients with AD, whereas CSF A beta 38 and A beta 40 levels were similar in patients with AD and control subjects. All three A beta peptides were interrelated, particularly CSF A beta 38 and A beta 40. Diagnostic accuracy of CSF A beta 42 concentrations was not improved by applying the ratios of CSF A beta 42 to A beta 38 or A beta 40.

引用

页码：139 / 142

页数：4