Chicoric acid ameliorate inflammation and oxidative stress in Lipopolysaccharide and d-galactosamine induced acute liver injury

被引：55

作者：

Li, Zheng ^{[1
]}

Feng, Haihua ^{[1
]}

Han, Lu ^{[1
]}

Ding, Lu ^{[1
]}

Shen, Bingyu ^{[1
]}

Tian, Ye ^{[1
]}

Zhao, Lilei ^{[1
]}

Jin, Meiyu ^{[1
]}

Wang, Qi ^{[1
]}

Qin, Haiyan ^{[1
]}

Cheng, Jiaqi ^{[1
]}

Liu, Guowen ^{[1
]}

机构：

[1] Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis, Changchun, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020年 / 24卷 / 05期

基金：

中国国家自然科学基金;

关键词：

acute liver injury; AMPK; autophagy; CA; d-GalN; LPS; MAPK; NF-kappa B; Nrf2; AUTOPHAGY; NRF2; INHIBITION;

D O I：

10.1111/jcmm.14935

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Chicoric acid is polyphenol of natural plant and has a variety of bioactivity. Caused by various kinds of stimulating factors, acute liver injury has high fatality rate. The effect of chicoric acid in acute liver injury induced by Lipopolysaccharide (LPS) and d-galactosamine (d-GalN) was investigated in this study. The results showed that CA decreased the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and reduced the mortality induced by LPS/d-GalN. CA can restrain mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B) to alleviate inflammation. Meanwhile, the results indicated CA can active nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway with increasing the level of AMP-activated protein kinase (AMPK). And with the treatment of CA, protein levels of autophagy genes were obvious improved. The results of experiments indicate that CA has protective effect in liver injury, and the activation of AMPK and autophagy may make sense.

引用

页码：3022 / 3033

页数：12

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