Inhibition of breast adenocarcinoma growth by intratumoral injection of lipophilic long-acting lathyrogens

Prevention of the formation of crosslinks and/or disintegration of already formed Collagen fibrils in the tumor by known lathyrogens, beta-aminopropionitrile or D-penicillamine, may result in the weakening of tumor support, decreasing angiogenesis and promoting tumor regression. This paper reviews our studies with a single intratumoral injection of lipophilic lathyrogens and others, using a systemic administration to investigate the effect of both lathyrogens. Details of our experimental results are also given. (C) 2005 Lippincott Williams Wilkins.