Inhibition of breast adenocarcinoma growth by intratumoral injection of lipophilic long-acting lathyrogens

被引：14

作者：

Chvapil, M

机构：

[1] Univ Arizona, Dept Surg, Tucson, AZ USA

[2] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA

来源：

ANTI-CANCER DRUGS | 2005年 / 16卷 / 02期

关键词：

angiogenesis; collagen structure; D-penicillamine methyl and hexyl esters; hexyl-3-(imino)propionitrile; lathyrogen; mammary adenocarcinoma tumor stability; matrix metalloproteinases; Schiff base crosslinks;

D O I：

10.1097/00001813-200502000-00013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prevention of the formation of crosslinks and/or disintegration of already formed Collagen fibrils in the tumor by known lathyrogens, beta-aminopropionitrile or D-penicillamine, may result in the weakening of tumor support, decreasing angiogenesis and promoting tumor regression. This paper reviews our studies with a single intratumoral injection of lipophilic lathyrogens and others, using a systemic administration to investigate the effect of both lathyrogens. Details of our experimental results are also given. (C) 2005 Lippincott Williams Wilkins.

引用

页码：201 / 210

页数：10

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