An efficient and practical method for the synthesis of mono-N-protected α,ω-diaminoalkanes

被引：47

作者：

Lee, JW

Jun, SI

Kim, K

机构：

[1] Pohang Univ Sci & Technol, Natl Creat Res Initiat Ctr Smart Supramol, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, South Korea

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 14期

关键词：

mono-protection; alpha; omega-diaminoalkanes; azides; reduction;

D O I：

10.1016/S0040-4039(01)00282-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) alpha,omega -diaminoalkanes (the number of carbon atoms = 3, 4, 5 and 6) are accomplished in 81-945 yield by the protection of amine and subsequent reduction of an azido group from alpha,omega -azido alkyl amines. alpha,omega -Azido alkyl amines are prepared efficiently by the partial reduction of alpha,omega -diazidoalkanes which are obtained from the corresponding dibromoalkanes. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2709 / 2711

页数：3

共 35 条

[1] SELECTIVE PROTECTION OF MIXED PRIMARY-SECONDARY AMINES - SIMPLE PREPARATION OF N1,N8-BIS(T-BUTOXYCARBONYL)SPERMIDINE [J].