A novel solid-phase reductive alkylation route to acridine and dansyl polyamine conjugates

被引：20

作者：

Carrington, S

Renault, J

Tomasi, S

Corbel, JC

Uriac, P

Blagbrough, IS ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

[2] Univ Rennes 1, Fac Pharm, F-35043 Rennes, France

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 14期

关键词：

D O I：

10.1039/a904023d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solid-phase organic synthesis (SPOS) routes to target unsymmetrical polyamines and their acridinyl and dansyl conjugates have been developed based upon borane-pyridine complex (BAP) mediated reductive alkylation, azide reduction with triphenylphosphine, and the use of pent-4-enoyl (Pnt) as an orthogonal amine protecting group.

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收藏

页码：1341 / 1342

页数：2

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