SYNTHESIS AND ASSAY OF HYBRID ANALOGS OF ARGIOTOXIN-636 AND PHILANTHOTOXIN-433 - GLUTAMATE-RECEPTOR ANTAGONISTS

被引：29

作者：

CHOI, SK

NAKANISHI, K

USHERWOOD, PNR

机构：

[1] UNIV NOTTINGHAM,DEPT LIFE SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

TETRAHEDRON | 1993年 / 49卷 / 26期

关键词：

ARGIOTOXIN-636; PHILANTHOTOXIN-433; GLUTAMATE RECEPTOR ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SELECTIVE ANTAGONISM; PHOTOAFFINITY LABEL; POLYAMINE-AMIDE TOXINS;

D O I：

10.1016/S0040-4020(01)87944-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on glutamate receptors are discussed.

引用

页码：5777 / 5790

页数：14

共 33 条

[1] STRUCTURES AND BIOLOGICAL-ACTIVITIES OF 3 SYNAPTIC ANTAGONISTS FROM ORB WEAVER SPIDER VENOM
ADAMS, ME
CARNEY, RL
ENDERLIN, FE
FU, ET
JAREMA, MA
LI, JP
MILLER, CA
SCHOOLEY, DA
SHAPIRO, MJ
VENEMA, VJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) : 678 - 683
[2] ADAMS ME, 1987, BIOCHEM BIOPH RES CO, V148, P6378
[3] ANIS N, 1990, J PHARMACOL EXP THER, V254, P764
[4] ARANIAKI Y, 1986, P JAPAN ACAD B, V62, P359
[5] ATWELL GJ, 1984, SYNTHESIS-STUTTGART, P1032
[6] BRACKLEY PTH, 1992, UNPUB J PHARM EXP TH
[7] BRAESTRUP C, 1991, TXB DRUG DESIGN DEV, P335
[8] QUATERNARY STRUCTURE OF THE ACETYLCHOLINE-RECEPTOR
BRISSON, A
UNWIN, PNT
[J]. NATURE, 1985, 315 (6019) : 474 - 477
[9] STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS OF THE WASP TOXIN PHILANTHOTOXIN - NONCOMPETITIVE ANTAGONISTS OF QUISQUALATE RECEPTORS
BRUCE, M
BUKOWNIK, R
ELDEFRAWI, AT
ELDEFRAWI, ME
GOODNOW, R
KALLIMOPOULOS, T
KONNO, K
NAKANISHI, K
NIWA, M
USHERWOOD, PNR
[J]. TOXICON, 1990, 28 (11) : 1333 - 1346
[10] CHILES G, 1992, NEUROTOX 91, P3

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