Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA

被引：25

作者：

Blagbrough, IS

Taylor, S

Carpenter, ML

Novoselskiy, V

Shamma, T

Haworth, IS

机构：

[1] Univ So Calif, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA

[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

[3] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 08期

关键词：

D O I：

10.1039/a709193a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-1-(Acridin-9-ylcarbonyl)spermine binds at 5'-pu-p-pu..5'-py-p-py sites of DNA with the acridine moiety asymmetrically intercalated, stacked between the two purine bases; the spermine moiety interacts with the homopyrimidine phosphodiester backbone of the intercalation site and protects against DNase I cleavage of this backbone, but does not protect against cleavage of the homopurine backbone at the same intercalation site.

引用

收藏

页码：929 / 930

页数：2

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