Selected reaction monitoring applied to proteomics

被引：228

作者：

Gallien, Sebastien ^{[1
]}

Duriez, Elodie ^{[1
]}

Domon, Bruno ^{[1
]}

机构：

[1] Ctr Rech Publ Sante, Luxembourg Clin Prote Ctr, L-1445 Strassen, Luxembourg

来源：

JOURNAL OF MASS SPECTROMETRY | 2011年 / 46卷 / 03期

关键词：

selected reaction monitoring; proteomics; quantification; triple quadrupole mass spectrometer; multiplexing; TANDEM MASS-SPECTROMETRY; PEPTIDE IMMUNOAFFINITY ENRICHMENT; PROSTATE-SPECIFIC ANTIGEN; ABSOLUTE QUANTIFICATION; QUANTITATIVE-ANALYSIS; HUMAN PLASMA; PROTEOTYPIC PEPTIDES; MULTIPLEXED ASSAYS; ACCURATE MASS; HUMAN SERUM;

D O I：

10.1002/jms.1895

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Selected reaction monitoring (SRM) performed on triple quadrupole mass spectrometers has been the reference quantitative technique to analyze small molecules for several decades. It is now emerging in proteomics as the ideal tool to complement shotgun qualitative studies; targeted SRM quantitative analysis offers high selectivity, sensitivity and a wide dynamic range. However, SRM applied to proteomics presents singularities that distinguish it from small molecules analysis. This review is an overview of SRM technology and describes the specificities and the technical aspects of proteomics experiments. Ongoing developments aiming at increasing multiplexing capabilities of SRM are discussed; they dramatically improve its throughput and extend its field of application to directed or supervised discovery experiments. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：298 / 312

页数：15

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