Where, in antiviral defense, does IFIT1 fit?

被引：5

作者：

Ablasser, Andrea ^{[1
]}

Hornung, Veit ^{[1
]}

机构：

[1] Univ Bonn, Inst Clin Chem & Pharmacol, Unit Clin Biochem, Univ Hosp, D-5300 Bonn, Germany

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 07期

关键词：

RIG-I; VIRUS-INFECTION; RNA; FAMILY; MDA5;

D O I：

10.1038/ni.2061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

New data show that the interferon-induced gene product IFIT1 is a sensor for 5'-triphosphorylated RNA of viral origin and that it functions within a larger IFIT complex to inhibit viral replication.

引用

页码：588 / 590

页数：4

共 10 条

[1] 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members [J].

Daffis, Stephane ;

Szretter, Kristy J. ;

Schriewer, Jill ;

Li, Jianqing ;

Youn, Soonjeon ;

Errett, John ;

Lin, Tsai-Yu ;

Schneller, Stewart ;

Zust, Roland ;

Dong, Hongping ;

Thiel, Volker ;

Sen, Ganes C. ;

Fensterl, Volker ;

Klimstra, William B. ;

Pierson, Theodore C. ;

Buller, R. Mark ;

Gale, Michael, Jr. ;

Shi, Pei-Yong ;

Diamond, Michael S. .

NATURE, 2010, 468 (7322) :452-456

[2] The ISG56/IFIT1 Gene Family [J].

Fensterl, Volker ;

Sen, Ganes C. .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2011, 31 (01) :71-78

[3] 5′-triphosphate RNA is the ligand for RIG-I [J].

Hornung, Veit ;

Ellegast, Jana ;

Kim, Sarah ;

Brzozka, Krzysztof ;

Jung, Andreas ;

Kato, Hiroki ;

Poeck, Hendrik ;

Akira, Shizuo ;

Conzelmann, Karl-Klaus ;

Schlee, Martin ;

Endres, Stefan ;

Hartmann, Gunther .

SCIENCE, 2006, 314 (5801) :994-997

[4] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses [J].

Kato, H ;

Takeuchi, O ;

Sato, S ;

Yoneyama, M ;

Yamamoto, M ;

Matsui, K ;

Uematsu, S ;

Jung, A ;

Kawai, T ;

Ishii, KJ ;

Yamaguchi, O ;

Otsu, K ;

Tsujimura, T ;

Koh, CS ;

Sousa, CRE ;

Matsuura, Y ;

Fujita, T ;

Akira, S .

NATURE, 2006, 441 (7089) :101-105

[5] RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates [J].

Pichlmair, Andreas ;

Schulz, Oliver ;

Tan, Choon Ping ;

Naslund, Tanja I. ;

Liljestrom, Peter ;

Weber, Friedemann ;

Sousa, Caetano Reis E. .

SCIENCE, 2006, 314 (5801) :997-1001

[6] IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA [J].

Pichlmair, Andreas ;

Lassnig, Caroline ;

Eberle, Carol-Ann ;

Gorna, Maria W. ;

Baumann, Christoph L. ;

Burkard, Thomas R. ;

Buerckstuemmer, Tilmann ;

Stefanovic, Adrijana ;

Krieger, Sigurd ;

Bennett, Keiryn L. ;

Ruelicke, Thomas ;

Weber, Friedemann ;

Colinge, Jacques ;

Mueller, Mathias ;

Superti-Furga, Giulio .

NATURE IMMUNOLOGY, 2011, 12 (07) :624-U177

[7] RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection [J].

Rehwinkel, Jan ;

Tan, Choon Ping ;

Goubau, Delphine ;

Schulz, Oliver ;

Pichlmair, Andreas ;

Bier, Katja ;

Robb, Nicole ;

Vreede, Frank ;

Barclay, Wendy ;

Fodor, Ervin ;

Reis e Sousa, Caetano .

CELL, 2010, 140 (03) :397-U143

[8] A diverse range of gene products are effectors of the type I interferon antiviral response [J].

Schoggins, John W. ;

Wilson, Sam J. ;

Panis, Maryline ;

Murphy, Mary Y. ;

Jones, Christopher T. ;

Bieniasz, Paul ;

Rice, Charles M. .

NATURE, 2011, 472 (7344) :481-U545

[9] Innate immunity to virus infection [J].

Takeuchi, Osamu ;

Akira, Shizuo .

IMMUNOLOGICAL REVIEWS, 2009, 227 :75-86

[10] Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [J].

Zuest, Roland ;

Cervantes-Barragan, Luisa ;

Habjan, Matthias ;

Maier, Reinhard ;

Neuman, Benjamin W. ;

Ziebuhr, John ;

Szretter, Kristy J. ;

Baker, Susan C. ;

Barchet, Winfried ;

Diamond, Michael S. ;

Siddell, Stuart G. ;

Ludewig, Burkhard ;

Thiel, Volker .

NATURE IMMUNOLOGY, 2011, 12 (02) :137-U46

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