Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy

被引：4

作者：

Tomino, Y

Suzuki, S

Gohda, T

Kobayashi, M

Horikoshi, S

Imai, H

Saito, T

Kawamura, T

Yorioka, N

Harada, T

Yasumoto, Y

Kida, H

Kobayashi, Y

Endoh, M

Sato, H

Saito, K

机构：

[1] Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 113, Japan

[2] Akita Univ, Sch Med, Dept Internal Med 3, Akita, Japan

[3] Tohoku Univ, Sch Med, Dept Internal Med 2, Sendai, Miyagi 980, Japan

[4] Jikei Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan

[5] Hiroshima Univ, Sch Med, Dept Internal Med 2, Hiroshima, Japan

[6] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan

[7] Kagoshima Univ, Sch Med, Fac Med, Dept Internal Med 2, Kagoshima 890, Japan

[8] Kanazawa Natl Hosp, Dept Internal Med 1, Kanazawa, Ishikawa, Japan

[9] Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 228, Japan

[10] Tokai Univ, Sch Med, Dept Internal Med, Div Nephrol & Metab, Isehara, Kanagawa 25911, Japan

[11] Sapporo City Gen Hosp, Dept Pathol, Cent Lab, Sapporo, Hokkaido, Japan

[12] Dade Behring Ltd, Mkt Div, Tokyo, Japan

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2001年 / 15卷 / 01期

关键词：

serum cystatin C; prognostic stage; IgA nephropathy;

D O I：

10.1002/1098-2825(2001)15:1<25::AID-JCLA5>3.0.CO;2-Y

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The relationship between the levels of serum cystatin C and the prognostic stages of IgA nephropathy was determined in a multicenter trial in Japan. The levels of serum cystatin C in patients with IgA nephropathy were measured using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Committee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health and Welfare of Japan, and the Japanese Society of Nephropathy reported four prognostic stages. These are: good prognosis group (Group I), relatively good prognosis group (Group II), relatively poor prognosis group (Group III), and poor prognosis group (Group IV), for this disease. Three-hundred and six patients with IgA nephropathy and other glomerular diseases were examined. There were no significant changes in the levels of serum creatinine (Cr) or creatinine clearance (CCr) between Group I and Group II. The mean levels of serum cystatin C in Group II were significantly higher than those in Group I (P < 0.05). The mean levels of serum cystatin C in Group III or IV were significantly higher than those in Group I (P < 0.001, P < 0.005, respectively). These suggest that the measurement of serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy. J. Clin. Lab. Anal. 15:25-29, 2001. (C) 2001 Wiley-Liss, Inc.

引用

页码：25 / 29

页数：5

共 13 条

[1] THE PLACE OF HUMAN GAMMA-TRACE (CYSTATIN-C) AMONGST THE CYSTEINE PROTEINASE-INHIBITORS [J].