Use of polymer supported reagents for clean multi-step organic synthesis:: preparation of amines and amine derivatives from alcohols for use in compound library generation

被引：62

作者：

Ley, SV

Bolli, MH

Hinzen, B

Gervois, AG

Hall, BJ

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Cambridge Combinatorial Ltd, Merrifield Ctr, Cambridge CB1 3LQ, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 15期

关键词：

D O I：

10.1039/a803611j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The automated sequential application of polymer supported perruthenate (PSP) and polymer supported cyanoborohydride (PSCBH) in an oxidation-reductive amination procedure allowed the efficient transformation of simple alcohols into more complex amines which can be further derivatised by the use of polymer bound amino sulfonylpyridinium chlorides.

引用

页码：2239 / 2241

页数：3

共 21 条

[1] APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS
AKELAH, A
SHERRINGTON, DC
[J]. CHEMICAL REVIEWS, 1981, 81 (06) : 557 - 587
[2] Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries
Boger, DL
Tarby, CM
Myers, PL
Caporale, LH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (08) : 2109 - 2110
[3] Polymer-supported quenching reagents for parallel purification
Booth, RJ
Hodges, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) : 4882 - 4886
[4] Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
Cheng, S
Comer, DD
Williams, JP
Myers, PL
Boger, DL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) : 2567 - 2573
[5] Combinatorial synthesis of dihydropyridone libraries and their derivatives
Creswell, MW
Bolton, GL
Hodges, JC
Meppen, M
[J]. TETRAHEDRON, 1998, 54 (16) : 3983 - 3998
[6] CURRAN DP, 1996, CHEMTRACTS ORG CHEM, V9, P75
[7] Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition
Flynn, DL
Crich, JZ
Devraj, RV
Hockerman, SL
Parlow, JJ
South, MS
Woodard, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) : 4874 - 4881
[8] Ion-exchange resins for solution phase parallel synthesis of chemical libraries
Gayo, LM
Suto, MJ
[J]. TETRAHEDRON LETTERS, 1997, 38 (04) : 513 - 516
[9] Synthesis of isoxazolidines using polymer supported perruthenate (PSP)
Hinzen, B
Ley, SV
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (01): : 1 - 2
[10] Polymer supported perruthenate (PSP): A new oxidant for clean organic synthesis
Hinzen, B
Ley, SV
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (13): : 1907 - 1908

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