Long noncoding RNAs in cell biology

被引：328

作者：

Clark, Michael B. ^{[1
]}

Mattick, John S. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

Trafficking; Paraspeckles; Localization; Nucleus; Cytoplasm; Neurons; Development; NEURONAL BC1 RNA; GENOME-WIDE IDENTIFICATION; MEIOTIC REGULATOR MEI2P; REPEAT-CONTAINING RNA; MESSENGER-RNA; GENE-EXPRESSION; ANTISENSE RNA; X-CHROMOSOME; POLY(A)-BINDING PROTEIN; DENDRITIC LOCATION;

D O I：

10.1016/j.semcdb.2011.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Whole genome transcriptomic analyses have identified large numbers of dynamically expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose functions are, as yet, largely unknown. Here we summarize the growing evidence that lncRNAs, like mRNAs, can be trafficked to and function in a wide variety of subcellular locations. Investigation of the subcellular distribution of lncRNAs has the potential to greatly expand our knowledge not only of the function of lncRNAs but also of cell biology by identifying previously unknown subcellular structures and novel constituents of known cellular organelles. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：366 / 376

页数：11

共 178 条

[61] Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo [J].

Lanz, RB ;

Chua, SS ;

Barron, N ;

Söder, BM ;

DeMayo, F ;

O'Malley, BW .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) :7163-7176

[62] A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex [J].

Lanz, RB ;

McKenna, NJ ;

Onate, SA ;

Albrecht, U ;

Wong, JM ;

Tsai, SY ;

Tsai, MJ ;

O'Malley, BW .

CELL, 1999, 97 (01) :17-27

[63] Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function [J].

Lecuyer, Eric ;

Yoshida, Hideki ;

Parthasarathy, Neela ;

Alm, Christina ;

Babak, Tomas ;

Cerovina, Tanja ;

Hughes, Timothy R. ;

Tomancak, Pavel ;

Krause, Henry M. .

CELL, 2007, 131 (01) :174-187

[64] Tsix, a gene antisense to Xist at the X-inactivation centre [J].

Lee, JT ;

Davidow, LS ;

Warshawsky, D .

NATURE GENETICS, 1999, 21 (04) :400-404

[65] Role of a neuronal small non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice [J].

Lewejohann, L ;

Skryabin, BV ;

Sachser, N ;

Prehn, C ;

Heiduschka, P ;

Thanos, S ;

Jordan, U ;

Dell'Omo, G ;

Vyssotski, AL ;

Pleskacheva, MG ;

Lipp, HP ;

Tiedge, H ;

Brosius, J ;

Prior, H .

BEHAVIOURAL BRAIN RESEARCH, 2004, 154 (01) :273-289

[66]

Leygue Etienne, 2007, Nucl Recept Signal, V5, pe006

[67] Role of human noncoding RNAs in the control of tumorigenesis [J].

Li, Ling ;

Feng, Tingting ;

Lian, Yingying ;

Zhang, Guangfeng ;

Garen, Alan ;

Song, Xu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (31) :12956-12961

[68] Translational control by a small RNA: Dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism [J].

Lin, Daisy ;

Pestova, Tatyana V. ;

Hellen, Christopher U. T. ;

Tiedge, Henri .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (09) :3008-3019

[69] A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas [J].

Lin, R. ;

Maeda, S. ;

Liu, C. ;

Karin, M. ;

Edgington, T. S. .

ONCOGENE, 2007, 26 (06) :851-858

[70] The human NTT gene: Identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4(+) T cells [J].

Liu, AY ;

Torchia, BS ;

Migeon, BR ;

Siliciano, RF .

GENOMICS, 1997, 39 (02) :171-184

← 2 3 4 5 6 7 8 9 10 11 →