A simple stereoselective synthesis and biological evaluation of FR181157: Orally active prostacyclin mimetic

被引：9

作者：

Hattori, K ^{[1
]}

Tabuchi, S ^{[1
]}

Okitsu, O ^{[1
]}

Taniguchi, K ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Med Chem Res Labs, Yodogawa Ku, Osaka 532, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.09.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic method of novel prostaglandin (PG) mimetic: FR181175 without PG skeleton are described. The key to success is creation of a chiral epoxide using Sharpless AD reaction with high ee yield. FR181157 shows high potency and agonist efficacy at the IP receptor and has good bioavailability. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4277 / 4279

页数：3

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