Cellular senescence and the aging brain

被引：198

作者：

Chinta, Shankar J. ^{[1
]}

Woods, Georgia ^{[1
]}

Rane, Anand ^{[1
]}

Demaria, Marco ^{[1
]}

Campisi, Judith ^{[1
,2
]}

Andersen, Julie K. ^{[1
]}

机构：

[1] Buck Inst Res Aging, Novato, CA 94945 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2015年 / 68卷

关键词：

Aging; Brain; Cellular senescence; Senescence associated secretory phenotype; Neurodegeneration; MOLECULAR-MECHANISMS; DAMAGE RESPONSE; GROWTH ARREST; IN-VIVO; CELLS; MICROGLIA; CANCER; RAT; AGE; FIBROBLASTS;

D O I：

10.1016/j.exger.2014.09.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Cellular senescence is a potent anti-cancermechanismthat arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of nonneuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies. (C) 2014 Elsevier Inc. All rights reserved.

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页码：3 / 7

页数：5

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