Making a vertebrate limb: new players enter from the wings

被引：49

作者：

Martin, G ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

BIOESSAYS | 2001年 / 23卷 / 10期

关键词：

D O I：

10.1002/bies.1126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

What initiates vertebrate limb development and induces limbs to form where they do? For several years the answer to this intriguing question has been framed in terms of a working model that limb induction depends on a dialogue between two members of the Fibroblast Growth Factor (FGF) family of intercellular signaling molecules, FGF8 and FGF10. Now, a recent paper has written roles for signals encoded by WNT genes, the vertebrate relatives of the Drosophila wingless gene, into the script.((1)) (C) 2001 John Wiley & Sons, Inc.

引用

页码：865 / 868

页数：4

共 23 条

[1] FIBROBLAST GROWTH-FACTORS INDUCE ADDITIONAL LIMB DEVELOPMENT FROM THE FLANK OF CHICK-EMBRYOS [J].

COHN, MJ ;

IZPISUABELMONTE, JC ;

ABUD, H ;

HEATH, JK ;

TICKLE, C .

CELL, 1995, 80 (05) :739-746

[2] Roles for FGF8 in the induction, initiation, and maintenance of chick limb development [J].

Crossley, PH ;

Minowada, G ;

MacArthur, CA ;

Martin, GR .

CELL, 1996, 84 (01) :127-136

[3]

FALLON JF, 1983, LIMB DEV REGENERATIO, P33

[4] WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo [J].

Kawakami, Y ;

Capdevila, J ;

Büscher, D ;

Itoh, T ;

Esteban, CR ;

Belmonte, JCI .

CELL, 2001, 104 (06) :891-900

[5] Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud [J].

Kengaku, M ;

Capdevila, J ;

Rodriguez-Esteban, C ;

De La Peña, J ;

Johnson, RL ;

Belmonte, JCI ;

Tabin, CJ .

SCIENCE, 1998, 280 (5367) :1274-1277

[6]

Klint Peter, 1999, Frontiers in Bioscience, V4, pD165, DOI 10.2741/Klint

[7] Fgf8 signalling from the AER is essential for normal limb development [J].

Lewandoski, M ;

Sun, X ;

Martin, GR .

NATURE GENETICS, 2000, 26 (04) :460-463

[8] The roles of FGFs in the early development of vertebrate limbs [J].

Martin, GR .

GENES & DEVELOPMENT, 1998, 12 (11) :1571-1586

[9] Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless [J].

Min, HS ;

Danilenko, DM ;

Scully, SA ;

Bolon, B ;

Ring, BD ;

Tarpley, JE ;

DeRose, M ;

Simonet, WS .

GENES & DEVELOPMENT, 1998, 12 (20) :3156-3161

[10] Fgf8 is required for outgrowth and patterning of the limbs [J].

Moon, AM ;

Capecchi, MR .

NATURE GENETICS, 2000, 26 (04) :455-459

← 1 2 3 →