Retrograde transport redux

被引：20

作者：

Chao, MV

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Dept Cell Biol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA

来源：

NEURON | 2003年 / 39卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(03)00401-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Trafficking of trophic factors in axons can occur in a retrograde and anterograde direction. Recent-findings bring further support for a vesicle-based process for retrograde transport but raise new questions that need to be pursued. Unraveling the exact mechanisms that account-for retrograde transport of neurotrophins and their receptors will reveal the cellular requirements for propagating trophic signals over long distances.

引用

收藏

页码：1 / 2

页数：2

相关论文

共 14 条

[1]

Bronfman FC, 2003, J NEUROSCI, V23, P3209

[2] NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals [J].

Delcroix, JD ;

Valletta, JS ;

Wu, CB ;

Hunt, SJ ;

Kowal, AS ;

Mobley, WC .

NEURON, 2003, 39 (01) :69-84

[3] Retrograde neurotrophin signaling: Trk-ing along the axon [J].

Ginty, DD ;

Segal, RA .

CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (03) :268-274

[4]

Grimes ML, 1996, J NEUROSCI, V16, P7950

[5] Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR [J].

Lalli, G ;

Schiavo, G .

JOURNAL OF CELL BIOLOGY, 2002, 156 (02) :233-239

[6] Activation of Trk neurotrophin receptors in the absence of neurotrophins [J].

Lee, FS ;

Chao, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3555-3560

[7] Retrograde support of neuronal survival without retrograde transport of nerve growth factor [J].

MacInnis, BL ;

Campenot, RB .

SCIENCE, 2002, 295 (5559) :1536-1539

[8] TRK makes the retrograde [J].

Miller, FD ;

Kaplan, DR .

SCIENCE, 2002, 295 (5559) :1471-+

[9] Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis [J].

Puthalakath, H ;

Villunger, A ;

O'Reilly, LA ;

Beaumont, JG ;

Coultas, L ;

Cheney, RE ;

Huang, DCS ;

Strasser, A .

SCIENCE, 2001, 293 (5536) :1829-1832

[10] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex [J].

Puthalakath, H ;

Huang, DCS ;

O'Reilly, LA ;

King, SM ;

Strasser, A .

MOLECULAR CELL, 1999, 3 (03) :287-296