FLT3: ITDoes matter in leukemia

被引：389

作者：

Levis, M

Small, D

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21231 USA

来源：

LEUKEMIA | 2003年 / 17卷 / 09期

关键词：

FLT3; AML; ITD; receptor tyrosine kinase; tyrosine kinase inhibitor;

D O I：

10.1038/sj.leu.2403099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FMS-like tyrosine kinase-3 (FLT3), a receptor tyrosine kinase, is important for the development of the hematopoietic and immune systems. Activating mutations of FLT3 are now recognized as the most common molecular abnormality in acute myeloid leukemia, and FLT3 mutations may play a role in other hematologic malignancies as well. The poor prognosis of patients harboring these mutations renders FLT3 an obvious target of therapy. This review summarizes the data on the molecular biology and clinical impact of FLT3 mutations, as well as the therapeutic potential of several small-molecule FLT3 inhibitors currently in development.

引用

收藏

页码：1738 / 1752

页数：15

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