Homeostatic proliferation of B cells

被引：37

作者：

Woodland, RT ^{[1
]}

Schmidt, MR ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Worcester, MA 01655 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期

关键词：

homeostatic proliferation; B cells; memory;

D O I：

10.1016/j.smim.2005.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naive B cells introduced into a lymphopenic host undergo antigen-independent proliferation which is inhibited in a cell dose dependent manner by feedback from mature B cells. Homeostatic proliferation is a generalized lymphocyte property with B cells sharing many of the inductive and regulatory characteristics established for naive and memory CD4(+) and CD8(+) T cells and NK cells. In this communication we discuss the cytokine requirements for B cell HP, extend the murine studies to human cells, and propose the hypothesis that B cell HP may provide an antigen-independent mechanism for maintaining B cell memory. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：209 / 217

页数：9

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