Potential therapeutic applications of some antinutritional plant secondary metabolites

被引:147
作者
Singh, B [1 ]
Bhat, TK [1 ]
Singh, B [1 ]
机构
[1] Indian Vet Res Inst, Reg Stn, Palampur 176061, Himachal Prades, India
关键词
plant secondary metabolites; antinutritional factors; therapeutic applications;
D O I
10.1021/jf021150r
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Plant-based formulations have been used since ancient times as remedial measures against various human and animal ailments. Over the past 20 years interest in traditional medicines has increased considerably in many parts of the world. Whereas modifications in lifestyles, including diet, have had a profound effect on the increased risks of various diseases, there is considerable scientific evidence, both epidemiological and experimental, regarding vegetables and fruits as key features of diets associated with reduced risks of diseases such as cancers and infections. This has led to the use of a number of phytometabolites as anticarcinogenic and cardioprotective agents, promoting a dramatic increase in their consumption as dietary supplements. There are changing perceptions regarding the therapeutic potential of various plant secondary metabolites (PSMs), some of which have also been known to possess certain antinutritional qualities. The knowledge gained at the cellular and molecular levels, and biological activities of PSMs including tannin-polyphenols, saponins, mimosine, flavonoids, terpenoids, and phytates, would be useful in planning for future epidemiological studies and human cancer prevention trials, especially when a large pure dosage is not the option to deliver the active compounds to many tissues. It is well observed that alteration of cell cycle regulatory gene expression is frequently found in tumor tissues or cancer cell lines, and studies have suggested that the herbal-based or plant-originated cell cycle regulators might represent a new set of potential targets for anticancer drugs. The recent upsurge of interest in this area of research and advances made therein indicate that the impact of a number of diseases affecting humans and animals may be lessened, if not prevented, by simple dietary intake of PSMs with putative therapeutic properties.
引用
收藏
页码:5579 / 5597
页数:19
相关论文
共 270 条
[1]  
ADAMS NR, 1995, J ANIM SCI, V73, P1509
[2]   INHIBITION OF HUMAN AROMATASE BY MAMMALIAN LIGNANS AND ISOFLAVONOID PHYTOESTROGENS [J].
ADLERCREUTZ, H ;
BANNWART, C ;
WAHALA, K ;
MAKELA, T ;
BRUNOW, G ;
HASE, T ;
AROSEMENA, PJ ;
KELLIS, JT ;
VICKERY, LE .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 44 (02) :147-153
[3]   DIETARY PHYTOESTROGENS AND CANCER - INVITRO AND INVIVO STUDIES [J].
ADLERCREUTZ, H ;
MOUSAVI, Y ;
CLARK, J ;
HOCKERSTEDT, K ;
HAMALAINEN, E ;
WAHALA, K ;
MAKELA, T ;
HASE, T .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 41 (3-8) :331-337
[5]   Phyto-oestrogens and Western diseases [J].
Adlercreutz, H ;
Mazur, W .
ANNALS OF MEDICINE, 1997, 29 (02) :95-120
[6]   Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens [J].
Ahmad, I ;
Beg, AZ .
JOURNAL OF ETHNOPHARMACOLOGY, 2001, 74 (02) :113-123
[7]   Growth-inhibitory effects of Galla Rhois derived tannins on intestinal bacteria [J].
Ahn, YJ ;
Lee, CO ;
Kweon, JH ;
Ahn, JW ;
Park, JH .
JOURNAL OF APPLIED MICROBIOLOGY, 1998, 84 (03) :439-443
[8]  
AKIYAMA T, 1987, J BIOL CHEM, V262, P5592
[9]  
Alaoui Katim, 1998, Annales Pharmaceutiques Francaises, V56, P220
[10]   Dual effects of phytoestrogens result in U-shaped dose-response curves [J].
Almstrup, K ;
Fernández, MF ;
Petersen, JH ;
Olea, N ;
Skakkebaek, NE ;
Leffers, H .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2002, 110 (08) :743-748