Type-2 copper-containing enzymes

被引:105
作者
MacPherson, I. S.
Murphy, M. E. P.
机构
[1] Univ British Columbia, Inst Life Sci, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Inst Life Sci, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
关键词
nitrite reductase; amine oxidase; superoxide dismutase; dopamine monooxygenase; peptidyl; amidating enzyme; VASCULAR ADHESION PROTEIN-1; CONTAINING NITRITE REDUCTASE; ZINC SUPEROXIDE-DISMUTASE; 2,4,5-TRIHYDROXYPHENYLALANINE QUINONE BIOGENESIS; ALPHA-HYDROXYLATING MONOOXYGENASE; DOPAMINE BETA-MONOOXYGENASE; CONTAINING AMINE OXIDASE; CRYSTAL-STRUCTURE; ACTIVE-SITE; ALCALIGENES-FAECALIS;
D O I
10.1007/s00018-007-7310-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Type-2 Cu sites are found in all the major branches of life and are often involved in the catalysis of oxygen species. Four type-2 Cu protein families are selected as model systems for review: amine oxidases, Cu monooxygenases, nitrite reductase/multicopper oxidase, and CuZn superoxide dismutase. For each model protein, the availability of multiple crystal structures and detailed enzymological studies provides a detailed molecular view of the type-2 Cu site and delineation of the mechanistic role of the Cu in biological function. Comparison of these model proteins leads to the identification of common properties of the Cu sites and insight into the evolution of the trinuclear active site found in multicopper oxidases.
引用
收藏
页码:2887 / 2899
页数:13
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