Resisting Targeted Therapy: Fifty Ways to Leave Your EGFR

被引：20

作者：

Workman, Paul ^{[1
]}

Clarke, Paul A. ^{[1
]}

机构：

[1] Inst Canc Res, Haddow Labs, Signal Transduct & Mol Pharmacol Team, Canc Res UK Canc Therapeut Unit,Div Canc Therapeu, Sutton SM2 5NG, Surrey, England

来源：

CANCER CELL | 2011年 / 19卷 / 04期

关键词：

LUNG-CANCER; INHIBITORS; ADDICTION; MUTATIONS;

D O I：

10.1016/j.ccr.2011.03.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the promise of the new generation of molecularly targeted drugs, intrinsic and acquired resistance is proving to be as problematic as with cytotoxic drugs. Two recent papers have identified novel ways by which non-small cell lung cancers can exhibit resistance to EGFR inhibitors and suggest new therapeutic workarounds.

引用

页码：437 / 440

页数：4

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