Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

被引:257
作者
Gardner, MJ
Bishop, R
Shah, T
de Villiers, EP
Carlton, JM
Hall, N
Ren, QH
Paulsen, IT
Pain, A
Berriman, M
Wilson, RJM
Sato, S
Ralph, SA
Mann, DJ
Xiong, ZK
Shallom, SJ
Weidman, J
Jiang, LX
Lynn, J
Weaver, B
Shoaibi, A
Domingo, AR
Wasawo, D
Crabtree, J
Wortman, JR
Haas, B
Angiuoli, SV
Creasy, TH
Lu, C
Suh, B
Silva, JC
Utterback, TR
Feldblyum, TV
Pertea, M
Allen, J
Nierman, WC
Taracha, ELN
Salzberg, SL
White, OR
Fitzhugh, HA
Morzaria, S
Venter, JC
Fraser, CM
Nene, V
机构
[1] Inst Genom Res TIGR, Rockville, MD 20850 USA
[2] Int Livestock Res Inst, Nairobi, Kenya
[3] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[4] Natl Inst Med Res, London NW7 1AA, England
[5] Inst Pasteur, F-75724 Paris, France
[6] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England
[7] Venter Inst, Rockville, MD 20850 USA
关键词
D O I
10.1126/science.1110439
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
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页码:134 / 137
页数:4
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