Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis

被引：29

作者：

Hensiek, AE ^{[1
]}

Roxburgh, R ^{[1
]}

Smilie, B ^{[1
]}

Coraddu, F ^{[1
]}

Åkesson, E ^{[1
]}

Holmans, P ^{[1
]}

Sawcer, SJ ^{[1
]}

Compston, DAS ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 143卷 / 1-2期

关键词：

multiple sclerosis; linkage; genome screen;

D O I：

10.1016/j.jneuroim.2003.08.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 microsatellite markers. These data have been analysed together with those previously published, resulting in the largest currently available whole genome linkage dataset from a single population in multiple sclerosis. Four new regions of potential linkage (chromosomes 10p, 11p, 19p, 20p) not previously described were identified. In the combined analysis of all 226 families, a total of five regions of suggestive linkage are seen (chromosomes 1p, 6p, 14q, 17q, Xq), where only one would have been expected to occur by chance alone. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：25 / 30

页数：6

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