Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial

被引：156

作者：

Gori, A. ^{[1
]}

Rizzardini, G. ^{[2
]}

van't Land, B. ^{[3
,4
]}

Amor, K. B. ^{[3
]}

van Schaik, J. ^{[3
]}

Torti, C. ^{[5
]}

Quirino, T. ^{[6
]}

Tincati, C. ^{[7
]}

Bandera, A. ^{[1
]}

Knol, J. ^{[3
]}

Benlhassan-Chahour, K. ^{[9
]}

Trabattoni, D. ^{[8
]}

Bray, D. ^{[9
]}

Vriesema, A. ^{[3
]}

Welling, G. ^{[10
]}

Garssen, J. ^{[3
,4
]}

Clerici, M. ^{[11
,12
]}

机构：

[1] Univ Milano Bicocca, San Gerardo Hosp, Dept Internal Med, Div Infect Dis, Monza, Italy

[2] Luigi Sacco Hosp, Dept Infect Dis & Trop Med, Milan, Italy

[3] Danone Res Ctr Specialised Nutr, Wageningen, Netherlands

[4] Univ Utrecht, Div Pharmacol, Utrecht, Netherlands

[5] Univ Brescia, Clin Infect Dis, Brescia, Italy

[6] Busto Arsizio Hosp, Infect Dis Unit, Busto Arsizio, Italy

[7] Univ Milan, San Paolo Hosp, Clin Infect Dis, Dept Internal Med, Milan, Italy

[8] Univ Milan, DISP LITA Vialba, Chair Immunol, Milan, Italy

[9] ImmunoClin, Paris, France

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, NL-9713 AV Groningen, Netherlands

[11] Univ Milan, Dept Biomed Sci & Technol, I-20133 Milan, Italy

[12] IRCCS, Don C Gnocchi Fdn, Lab Mol Med & Biotechnol, Milan, Italy

来源：

MUCOSAL IMMUNOLOGY | 2011年 / 4卷 / 05期

关键词：

IN-SITU HYBRIDIZATION; T-CELL-ACTIVATION; GASTROINTESTINAL-TRACT; TYPE-1; INFECTION; KILLER-CELL; BACTERIA; BIFIDOBACTERIA; INTERVENTION; PATHOGENESIS; IMPAIRMENT;

D O I：

10.1038/mi.2011.15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intestinal mucosal immune system is an early target for human immunodeficiency virus type 1 (HIV-1) infection, resulting in CD4(+) T-cell depletion, deterioration of gut lining, and fecal microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides/long chain fructooligosaccharides/pectin hydrolysate-derived acidic oligosaccharides (scGOS/lcFOS/pAOS) daily) or a placebo for 12 weeks. Microbiota composition improved significantly with increased bifidobacteria, decreased Clostridium coccoides/Eubacterium rectale cluster, and decreased pathogenic Clostridium lituseburense/Clostridium histolyticum group levels upon prebiotic supplementation. In addition, a reduction of soluble CD14 (sCD14), activated CD4(+)/CD25(+) T cells, and significantly increased natural killer (NK) cell activity when compared with control group were seen in the treatment group. The results of this pilot trial highly significantly show that dietary supplementation with a prebiotic oligosaccharide mixture results in improvement of the gut microbiota composition, reduction of sCD14, CD4(+) T-cell activation (CD25), and improved NK cell activity in HAART-naive HIV-infected individuals.

引用

页码：554 / 563

页数：10

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