The rise and fall of mutator bacteria

被引：108

作者：

Giraud, A ^{[1
]}

Radman, M ^{[1
]}

Matic, I ^{[1
]}

Taddei, F ^{[1
]}

机构：

[1] Univ Paris 05, Fac Med Necker Enfants Malad, INSERM, F-75015 Paris, France

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(00)00254-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacteria with elevated mutation rates are frequently found among natural isolates. This is probably because of their ability to generate genetic variability, the substrate for natural selection. However, such high mutation rates can lead to the loss of vital functions. The evolution of bacterial populations may happen through alternating periods of high and low mutation rates. The cost and benefits of high mutation rates in the course of bacterial adaptive evolution are reviewed.

引用

页码：582 / 585

页数：4

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