3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium:: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

被引：142

作者：

Amoroso, Angelo J. ^{[1
]}

Arthur, Richard J. ^{[1
]}

Coogan, Michael P. ^{[1
]}

Court, Jonathan B. ^{[2
]}

Fernandez-Moreira, Vanesa ^{[1
]}

Hayes, Anthony J. ^{[3
]}

Lloyd, David ^{[2
]}

Millet, Coralie ^{[2
]}

Pope, Simon J. A. ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3AT, S Glam, Wales

[2] Cardiff Sch Biosci, Cardiff CF10 3TL, S Glam, Wales

[3] Cardiff Sch Biosci, Confocal Microscopy Unit, Cardiff CF10 3US, S Glam, Wales

来源：

NEW JOURNAL OF CHEMISTRY | 2008年 / 32卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b802215a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 3-chloromethylpyridyl bipyridine fac tricarbonyl rhenium cation is a thiol-reactive luminescent agent with a long luminescence lifetime and large Stokes shift that is demonstrated by colocalisation studies to accumulate in mitochondria. This represents the first application of a (MLCT)-M-3 luminescent agent for the specific targeting of a biological entity in imaging.

引用

页码：1097 / 1102

页数：6

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