Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregivers

被引：60

作者：

Aschbacher, Kirstin ^{[1
,2
]}

Mills, Paul J. ^{[1
]}

von Kaenel, Roland ^{[1
,3
]}

Hong, Suzi ^{[1
]}

Mausbach, Brent T. ^{[1
,4
]}

Roepke, Susan K. ^{[1
,2
]}

Dimsdale, Joel E. ^{[1
]}

Patterson, Thomas L. ^{[1
,4
]}

Ziegler, Michael G. ^{[5
]}

Ancoli-Israel, Sonia ^{[1
,4
]}

Grant, Igor ^{[1
,4
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA

[2] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA

[3] Univ Hosp Bern, Dept Gen Internal Med, Bern, Switzerland

[4] San Diego Vet Affairs Healthcare Syst, San Diego, CA USA

[5] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2008年 / 22卷 / 04期

关键词：

coagulation; hemostasis; platelet hyperreactivity; prolonged platelet activation; chronic stress; cardiovascular disease; atherosclerosis; catecholamines; sympathetic nervous system; Alzheimer's disease; dementia; psychocardiology; negative affect;

D O I：

10.1016/j.bbi.2007.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Caring for a spouse with Alzheimer's disease is associated with increased psychological distress, impaired immunity, and heightened cardiovascular risk. Hyperreactivity of sympathetic and platelet activation responses to acute psychological stress, or the failure to recover quickly from stressful events, may constitute an important pathway linking stress and negative affect with cardiovascular disease (CVD). Objectives: (1) To evaluate associations between negative affect (i.e., depressive and anxious symptoms) with increased norepinephrine and P-selectin responses to an acute psychological stress task. (2) To establish whether these associations are augmented among elderly spousal caregivers (CG) compared to non-caregivers (NC). Methods: Depressive (DEP) and anxious (ANX) symptoms from the Brief Symptom Inventory were assessed among 39 CG and 31 NC. Plasma norepinephrine levels (NE) and percent platelet P-selectin (PSEL) expression were assayed at three time-points: rest, immediately following a laboratory speech test (reactivity), and after 14 min of recovery. Results: Among CG, but not NC, increased symptoms of depression and anxiety were associated with delayed NE recovery (DEP: beta = .460, p = .008; ANX: beta = 361, p = .034), increased PSEL reactivity (DEP: beta = .703, p < .001; ANX: beta = .526, p = .002), and delayed PSEL recovery (DEP: beta = .372, p = .039; ANX: beta = .295, p = .092), while controlling for age, gender, aspirin use, antidepressant use, and preexisting CVD. Bivariate correlations showed delayed NE recovery was also associated with increased PSEL reactivity (r = .416) and delayed PSEL recovery (r = .372; all ps < .05) among CG but not NC. Discussion: Among chronically stressed caregivers, increased levels of depressive and anxious symptoms are associated with prolonged sympathetic activation and pronounced platelet activation. These changes may represent one pathway linking caregiving stress to cardiovascular risk. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：493 / 502

页数：10

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