Genetic markers of osteoarticular disorders: facts and hopes

被引:28
作者
Brandi, ML
Gennari, L
Cerinic, MM
Becherini, L
Falchetti, A
Masi, L
Gennari, C
Reginster, JY
机构
[1] Univ Florence, Dept Med, I-50135 Florence, Italy
[2] Univ Florence, Rheumatol Sect, Florence, Italy
[3] Univ Siena, Inst Internal Med, I-53100 Siena, Italy
[4] Univ Liege, Bone & Articular Cartilage Res Unit, B-4000 Liege, Belgium
关键词
candidate genes; genetics; multifactorial diseases; osteoporosis; osteoarthritis;
D O I
10.1186/ar316
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches.
引用
收藏
页码:270 / 280
页数:11
相关论文
共 149 条
[31]   EVIDENCE OF ESTROGEN-RECEPTORS IN NORMAL HUMAN OSTEOBLAST-LIKE CELLS [J].
ERIKSEN, EF ;
COLVARD, DS ;
BERG, NJ ;
GRAHAM, ML ;
MANN, KG ;
SPELSBERG, TC ;
RIGGS, BL .
SCIENCE, 1988, 241 (4861) :84-86
[32]  
Felson DT, 1998, ARTHRITIS RHEUM, V41, P1064, DOI 10.1002/1529-0131(199806)41:6<1064::AID-ART13>3.0.CO
[33]  
2-K
[34]   VITAMIN-D-RECEPTOR-GENE POLYMORPHISMS AND CHANGE IN LUMBAR-SPINE BONE-MINERAL DENSITY [J].
FERRARI, S ;
RIZZOLI, R ;
CHEVALLEY, T ;
SLOSMAN, D ;
EISMAN, JA ;
BONJOUR, JP .
LANCET, 1995, 345 (8947) :423-424
[35]   Vitamin D receptor gene start codon polymorphisms (FokI) and bone mineral density:: Interaction with age, dietary calcium, and 3′-end region polymorphisms [J].
Ferrari, S ;
Rizzoli, R ;
Manen, D ;
Slosman, D ;
Bonjour, JP .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (06) :925-930
[36]   Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? [J].
Ferrari, SL ;
Rizzoli, R ;
Slosman, DO ;
Bonjour, JP .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (03) :363-370
[37]  
Garnero P, 1996, J BONE MINER RES, V11, P827
[38]  
GARNERO P, 1995, J BONE MINER RES, V10, P1283
[39]   Collagen Iα1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women:: The OFELY study [J].
Garnero, P ;
Borel, O ;
Grant, SFA ;
Ralston, SH ;
Delmas, PD .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (05) :813-817
[40]   Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women [J].
Gennari, L ;
Becherini, L ;
Masi, L ;
Gonnelli, S ;
Cepollaro, C ;
Martini, S ;
Mansani, R ;
Brandi, ML .
CALCIFIED TISSUE INTERNATIONAL, 1997, 61 (06) :460-463