Testing the Right Target and Right Drug at the Right Stage

被引:415
作者
Sperling, Reisa A. [1 ]
Jack, Clifford R., Jr. [2 ]
Aisen, Paul S. [3 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Alzheimer Res & Treatment,Brigham & Womens Ho, Boston, MA 02446 USA
[2] Mayo Clin, Dept Radiol, Rochester, MN 55902 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
关键词
MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; AMYLOID DEPOSITION; A-BETA; CSF BIOMARKERS; ASSOCIATION; MRI; RECOMMENDATIONS; PROGRESSION; PREDICTION;
D O I
10.1126/scitranslmed.3002609
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Alzheimer's disease (AD) is the only leading cause of death for which no disease-modifying therapy is currently available. Recent disappointing trial results at the dementia stage of AD have raised multiple questions about our current approaches to the development of disease-modifying agents. Converging evidence suggests that the pathophysiological process of AD begins many years before the onset of dementia. So why do we keep testing drugs aimed at the initial stages of the disease process in patients at the end-stage of the illness?
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页数:5
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共 36 条
  • [1] Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
    Bateman, Randall J.
    Aisen, Paul S.
    De Strooper, Bart
    Fox, Nick C.
    Lemere, Cynthia A.
    Ringman, John M.
    Salloway, Stephen
    Sperling, Reisa A.
    Windisch, Manfred
    Xiong, Chengjie
    [J]. ALZHEIMERS RESEARCH & THERAPY, 2011, 3 (01)
  • [2] A γ-Secretase Inhibitor Decreases Amyloid-β Production in the Central Nervous System
    Bateman, Randall J.
    Siemers, Eric R.
    Mawuenyega, Kwasi G.
    Wen, Guolin
    Browning, Karen R.
    Sigurdson, Wendy C.
    Yarasheski, Kevin E.
    Friedrich, Stuart W.
    DeMattos, Ronald B.
    May, Patrick C.
    Paul, Steven M.
    Holtzman, David M.
    [J]. ANNALS OF NEUROLOGY, 2009, 66 (01) : 48 - 54
  • [3] Amyloid-β Associated Cortical Thinning in Clinically Normal Elderly
    Becker, J. Alex
    Hedden, Trey
    Carmasin, Jeremy
    Maye, Jacqueline
    Rentz, Dorene M.
    Putcha, Deepti
    Fischl, Bruce
    Greve, Douglas N.
    Marshall, Gad A.
    Salloway, Stephen
    Marks, Donald
    Buckner, Randy L.
    Sperling, Reisa A.
    Johnson, Keith A.
    [J]. ANNALS OF NEUROLOGY, 2011, 69 (06) : 1032 - 1042
  • [4] Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    Brys, Miroslaw
    Pirraglia, Elizabeth
    Rich, Kenneth
    Rolstad, Sindre
    Mosconi, Lisa
    Switalski, Remigiusz
    Glodzik-Sobanska, Lidia
    De Santi, Susan
    Zinkowski, Ray
    Mehta, Pankaj
    Pratico, Domenico
    Saint Louis, Leslie A.
    Wallin, Anders
    Blennow, Kaj
    de Leon, Mony J.
    [J]. NEUROBIOLOGY OF AGING, 2009, 30 (05) : 682 - 690
  • [5] Darby D. G., 2011, J ALZHEIMERS DI 0826
  • [6] Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults
    Fagan, Anne M.
    Roe, Catherine M.
    Xiong, Chengjie
    Mintun, Mark A.
    Morris, John C.
    Holtzman, David M.
    [J]. ARCHIVES OF NEUROLOGY, 2007, 64 (03) : 343 - 349
  • [7] PET imaging of amyloid deposition in patients with mild cognitive impairment
    Forsberg, Anton
    Engler, Henry
    Almkvist, Ove
    Blomquist, Gunnar
    Hagman, Goran
    Wall, Anders
    Ringheim, Anna
    Langstrom, Bengt
    Nordberg, Agneta
    [J]. NEUROBIOLOGY OF AGING, 2008, 29 (10) : 1456 - 1465
  • [8] Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    Fox, NC
    Black, RS
    Gilman, S
    Rossor, MN
    Griffith, SG
    Jenkins, L
    Koller, M
    [J]. NEUROLOGY, 2005, 64 (09) : 1563 - 1572
  • [9] GomezIsla T, 1996, J NEUROSCI, V16, P4491
  • [10] Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    Hansson, O
    Zetterberg, H
    Buchhave, P
    Londos, E
    Blennow, K
    Minthon, L
    [J]. LANCET NEUROLOGY, 2006, 5 (03) : 228 - 234