Cellular microbiology: can we learn cell physiology from microorganisms?

被引:27
作者
Fasano, A
机构
[1] Univ Maryland, Sch Med, Div Pediat Gastroenterol & Nutr, Ctr Vaccine Dev,Dept Pediat & Physiol, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Gastrointestinal Pathophysiol Sect, Ctr Vaccine Dev, Baltimore, MD 21201 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 1999年 / 276卷 / 04期
关键词
bacterial pathogenesis; enterotoxins; intracellular signaling; diarrhea; intestine;
D O I
10.1152/ajpcell.1999.276.4.C765
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular microbiology is a new discipline that is emerging at the interface between cell biology and microbiology. The application of molecular techniques to the study of bacterial pathogenesis has made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrheal diseases of necessity transcends established boundaries between cell biology, bacteriology, intestinal pathophysiology, and immunology. The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results.
引用
收藏
页码:C765 / C776
页数:12
相关论文
共 95 条
[1]  
[Anonymous], POWER UNSEEN MICROBE
[2]   INDUCTION OF MEMBRANE RUFFLING AND FLUID-PHASE PINOCYTOSIS IN QUIESCENT FIBROBLASTS BY RAS PROTEINS [J].
BARSAGI, D ;
FERAMISCO, JR .
SCIENCE, 1986, 233 (4768) :1061-1068
[3]   PURIFICATION AND FUNCTIONAL RECONSTITUTION OF THE CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) [J].
BEAR, CE ;
LI, CH ;
KARTNER, N ;
BRIDGES, RJ ;
JENSEN, TJ ;
RAMJEESINGH, M ;
RIORDAN, JR .
CELL, 1992, 68 (04) :809-818
[4]   ALTERED INTESTINAL CHLORIDE TRANSPORT IN CYSTIC-FIBROSIS [J].
BERSCHNEIDER, HM ;
KNOWLES, MR ;
AZIZKHAN, RG ;
BOUCHER, RC ;
TOBEY, NA ;
ORLANDO, RC ;
POWELL, DW .
FASEB JOURNAL, 1988, 2 (10) :2625-2629
[5]  
BIRNBAUMER L, 1987, KIDNEY INT, V32, pS14
[6]   SIGNAL-TRANSDUCTION IN THE MAMMALIAN-CELL DURING BACTERIAL ATTACHMENT AND ENTRY [J].
BLISKA, JB ;
GALAN, JE ;
FALKOW, S .
CELL, 1993, 73 (05) :903-920
[7]   CA IONOPHORE-STIMULATED ION SECRETION IN RABBIT ILEAL MUCOSA - RELATION TO ACTIONS OF CYCLIC 3',5'-AMP AND CARBAMYLCHOLINE [J].
BOLTON, JE ;
FIELD, M .
JOURNAL OF MEMBRANE BIOLOGY, 1977, 35 (02) :159-173
[8]   THE ESCHERICHIA-COLI HEAT-STABLE ENTEROTOXIN IS A LONG-LIVED SUPERAGONIST OF GUANYLIN [J].
CARPICK, BW ;
GARIEPY, J .
INFECTION AND IMMUNITY, 1993, 61 (11) :4710-4715
[9]  
CASEY PJ, 1988, J BIOL CHEM, V263, P2577
[10]  
Cereijido M, 1992, TIGHT JUNCTIONS, P1