Cellular microbiology: can we learn cell physiology from microorganisms?

被引:27
作者
Fasano, A
机构
[1] Univ Maryland, Sch Med, Div Pediat Gastroenterol & Nutr, Ctr Vaccine Dev,Dept Pediat & Physiol, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Gastrointestinal Pathophysiol Sect, Ctr Vaccine Dev, Baltimore, MD 21201 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 1999年 / 276卷 / 04期
关键词
bacterial pathogenesis; enterotoxins; intracellular signaling; diarrhea; intestine;
D O I
10.1152/ajpcell.1999.276.4.C765
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular microbiology is a new discipline that is emerging at the interface between cell biology and microbiology. The application of molecular techniques to the study of bacterial pathogenesis has made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrheal diseases of necessity transcends established boundaries between cell biology, bacteriology, intestinal pathophysiology, and immunology. The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results.
引用
收藏
页码:C765 / C776
页数:12
相关论文
共 95 条
[11]  
CHANG EB, 1984, GASTROENTEROLOGY ANN, V2, P158
[12]  
CHANG EB, 1983, GASTROENTEROLOGY ANN, V1, P148
[13]   A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR [J].
CHINKERS, M ;
GARBERS, DL ;
CHANG, MS ;
LOWE, DG ;
CHIN, HM ;
GOEDDEL, DV ;
SCHULZ, S .
NATURE, 1989, 338 (6210) :78-83
[14]   FRACTURE FACES OF ZONULAE OCCLUDENTES FROM TIGHT AND LEAKY EPITHELIA [J].
CLAUDE, P ;
GOODENOUGH, DA .
JOURNAL OF CELL BIOLOGY, 1973, 58 (02) :390-400
[15]  
COOKE HJ, 1987, PHYSL GASTROINTESTIN, P1307
[16]   Cellular microbiology emerging [J].
Cossart, P ;
Boquet, P ;
Normark, S ;
Rappuoli, R .
SCIENCE, 1996, 271 (5247) :315-316
[17]   GUANYLIN - AN ENDOGENOUS ACTIVATOR OF INTESTINAL GUANYLATE-CYCLASE [J].
CURRIE, MG ;
FOK, KF ;
KATO, J ;
MOORE, RJ ;
HAMRA, FK ;
DUFFIN, KL ;
SMITH, CE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (03) :947-951
[18]   KININS STIMULATE NET CHLORIDE SECRETION BY THE RAT COLON [J].
CUTHBERT, AW ;
MARGOLIUS, HS .
BRITISH JOURNAL OF PHARMACOLOGY, 1982, 75 (04) :587-598
[19]  
DEWOLF MJS, 1981, J BIOL CHEM, V256, P5489
[20]   THE NEUROHUMORAL SECRETAGOGUES CARBACHOL, SUBSTANCE-P AND NEUROTENSIN INCREASE CA++-INFLUX AND CALCIUM CONTENT IN RABBIT ILEUM [J].
DONOWITZ, M ;
FOGEL, R ;
BATTISTI, L ;
ASARKOF, N .
LIFE SCIENCES, 1982, 31 (18) :1929-1937