Complexity of EGF receptor signalling revealed in Drosophila

被引:51
作者
Freeman, M [1 ]
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
关键词
D O I
10.1016/S0959-437X(98)80110-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The multiple roles of the Drosophila epidermal growth factor receptor (EGFR) require that its activation is regulated precisely. Recent work has highlighted two important control mechanisms: the existence of multiple ligands with distinct properties and the interaction between EG FR pathway and other signalling pathways. The integration of signalling pathways into networks is beginning to be understood.
引用
收藏
页码:407 / 411
页数:5
相关论文
共 46 条
[31]   There must be 50 ways to rule the signal: The case of the Drosophila EGF receptor [J].
Perrimon, N ;
Perkins, LA .
CELL, 1997, 89 (01) :13-16
[32]  
Price JV, 1997, GENETICS, V147, P1139
[33]   THE DROSOPHILA-SPITZ GENE ENCODES A PUTATIVE EGF-LIKE GROWTH-FACTOR INVOLVED IN DORSAL VENTRAL AXIS FORMATION AND NEUROGENESIS [J].
RUTLEDGE, BJ ;
ZHANG, K ;
BIER, E ;
JAN, YN ;
PERRIMON, N .
GENES & DEVELOPMENT, 1992, 6 (08) :1503-1517
[34]   Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins [J].
Schnepp, B ;
Grumbling, G ;
Donaldson, T ;
Simcox, A .
GENES & DEVELOPMENT, 1996, 10 (18) :2302-2313
[35]   INHIBITION OF DROSOPHILA EGF RECEPTOR ACTIVATION BY THE SECRETED PROTEIN ARGOS [J].
SCHWEITZER, R ;
HOWES, R ;
SMITH, R ;
SHILO, BZ ;
FREEMAN, M .
NATURE, 1995, 376 (6542) :699-702
[36]   A thousand and one roles for the Drosophila EGF receptor [J].
Schweitzer, R ;
Shilo, BZ .
TRENDS IN GENETICS, 1997, 13 (05) :191-196
[37]   SECRETED SPITZ TRIGGERS THE DER SIGNALING PATHWAY AND IS A LIMITING COMPONENT IN EMBRYONIC VENTRAL ECTODERM DETERMINATION [J].
SCHWEITZER, R ;
SHAHARABANY, M ;
SEGER, R ;
SHILO, BZ .
GENES & DEVELOPMENT, 1995, 9 (12) :1518-1529
[38]   STRUCTURE AND FUNCTION OF HUMAN AMPHIREGULIN - A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY [J].
SHOYAB, M ;
PLOWMAN, GD ;
MCDONALD, VL ;
BRADLEY, JG ;
TODARO, GJ .
SCIENCE, 1989, 243 (4894) :1074-1076
[39]   Differential requirement for EGF-like ligands in Drosophila wing development [J].
Simcox, A .
MECHANISMS OF DEVELOPMENT, 1997, 62 (01) :41-50
[40]   Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction [J].
Szüts, D ;
Eresh, S ;
Bienz, M .
GENES & DEVELOPMENT, 1998, 12 (13) :2022-2035