CCR7 is involved in the migration of neutrophils to lymph nodes

被引：181

作者：

Beauvillain, Celine ^{[1
,2
,3
]}

Cunin, Pierre ^{[1
,2
]}

Doni, Andrea ^{[4
]}

Scotet, Mari ^{[1
,2
]}

Jaillon, Sebastien ^{[1
,2
,4
]}

Loiry, Marie-Line ^{[3
]}

Magistrelli, Giovanni ^{[5
]}

Masternak, Krzysztof ^{[5
]}

Chevailler, Alain ^{[1
,2
,3
]}

Delneste, Yves ^{[1
,2
,3
]}

Jeannin, Pascale ^{[1
,2
,3
]}

机构：

[1] CHU Angers, INSERM, U892, Ctr Rech Cancerol Nantes Angers, F-49933 Angers, France

[2] Univ Angers, UMR S 892, Angers, France

[3] CHU Angers, Lab Immunol & Allergol, F-49933 Angers, France

[4] Univ Milan, Ist Clin Humanitas, Milan, Italy

[5] Novimmune SA, Geneva, Switzerland

来源：

BLOOD | 2011年 / 117卷 / 04期

关键词：

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; POLYMORPHONUCLEAR NEUTROPHILS; DENDRITIC CELLS; IMMUNE-RESPONSE; CLASS-II; ACTIVATION; ANTIGEN; KILL; RECRUITMENT; EXPRESSION;

D O I：

10.1182/blood-2009-11-254490

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Increasing evidence suggests that neutrophils may participate in the regulation of adaptive immune responses, and can reach draining lymph nodes and cross-prime naive T cells. The aim of this study was to identify the mechanism(s) involved in the migration of neutrophils to the draining lymph nodes. We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation. In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. In vivo, injection of complete Freund adjuvant induces a rapid recruitment of neutrophils to the lymph nodes in wild-type mice but not in Ccr7(-/-) mice. Moreover, intradermally injected interleukin-17- and granulocyte-macrophage colony-stimulating factor-stimulated neutrophils from wild-type mice, but not from Ccr7(-/-) mice, migrate to the draining lymph nodes. These results identify CCR7 as a chemokine receptor involved in the migration of neutrophils to the lymph nodes. (Blood. 2011;117(4):1196-1204)

引用

页码：1196 / 1204

页数：9

共 46 条

[1]

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes [J].