Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer

被引：247

作者：

Yang, Jaemoon

Lee, Choong-Hwan

Ko, Hyun-Ju

Suh, Jin-Suck

Yoon, Ho-Geun

Lee, Kwangyeol

Huh, Yong-Min ^{[1
]}

Haam, Seungjoo

机构：

[1] Yonsei Univ, Dept Radiol, Dept Biochem & Mol Biol, Seoul 120752, South Korea

[2] Yonsei Univ, Dept Chem Engn, Seoul 120749, South Korea

[3] Adv Technol Res Ctr, ATGen, Seoul 463816, South Korea

[4] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 46期

关键词：

drug delivery; hybrid composites; imaging agents; magnetic resonance; transmission electron microscopy;

D O I：

10.1002/anie.200703554

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for targeted detection by MRI and treatment of breast cancer. See the TEM image (left) of an MMPN and T 2-weighted MR images (top row) and color map (bottom row) of the relaxivity R2 for NIH3T6.7 and MDA-MB-231 cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：8836 / 8839

页数：4

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