Strong biofilm production, antibiotic multi-resistance and high gelE expression in epidemic clones of Enterococcus faecalis from orthopaedic implant infections

被引：74

作者：

Arciola, Carla Renata ^{[1
,2
]}

Baldassarri, Lucilla ^{[3
]}

Campoccia, Davide ^{[1
]}

Creti, Roberta ^{[3
]}

Pirini, Valter ^{[1
]}

Huebner, Johannes ^{[4
,5
]}

Montanaro, Lucio ^{[1
,2
]}

机构：

[1] Rizzoli Orthopaed Inst, Res Unit Implant Infect, I-40136 Bologna, Italy

[2] Univ Bologna, Dept Expt Pathol, I-40136 Bologna, Italy

[3] Ist Super Sanita, Dipartimento Malattie Infettive Parassitar & Immu, I-00161 Rome, Italy

[4] Univ Hosp, Dept Med, Div Infect Dis, Freiburg, Germany

[5] Harvard Med Sch, Brigham & Womens Hosp, Channing Lab, Boston, MA USA

来源：

BIOMATERIALS | 2008年 / 29卷 / 05期

关键词：

Enterococcus faecalis; biofilm; esp; gelE; antibiotic resistance; ribotyping;

D O I：

10.1016/j.biomaterials.2007.10.008

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Enterococcus faecalis is an opportunistic pathogen, which today represents one of the leading aetiologic agents of nosocomial infections and, increasingly, of implant infections. Here, in a collection of 43 E. faecalis isolated from implant orthopaedic infections, virulence-related phenotypes (biofilm and gelatinase production) and genotypes (gelE and esp) were studied to characterize epidemic clones identified and grouped by ribotyping. The presence of the esp gene and a marked and steady biofilm formation ability appeared to be the features associated with the clonal spreading, as well as a conspicuous gelatinase production, whereas the simple presence of gelE appeared non-specific of the epidemic clones. Antibiotic multi-resistance and strong biofilm production abilities together with a high phenotypic expression of gelatinase are an important equipment of E. faecalis to colonize peri-prosthesis tissues and to spread out as causative agents of implant orthopaedic infections. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：580 / 586

页数：7

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