SigB-dependent general stress response in Bacillus subtilis and related gram-positive bacteria

被引：356

作者：

Hecker, Michael ^{[1
]}

Pane-Farre, Jan

Voelker, Uwe

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Mikrobiol, D-17489 Greifswald, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Interfakultares Genet & Funktionalle Genomforschu, D-17489 Greifswald, Germany

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2007年 / 61卷

关键词：

low G plus C gram-positive bacteria; vegetative dormancy; multiple stress resistance; virulence; pathogenicity;

D O I：

10.1146/annurev.micro.61.080706.093445

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One of the strongest and most noticeable responses of Bacillus subtilis cells to a range of stress and starvation stimuli is the dramatic induction of about 150 SigB-dependent general stress genes. The activity of SigB itself is tightly regulated by a complex signal transduction cascade with at least three main signaling pathways that respond to environmental stress, energy depletion, or low temperature. The SigB-dependent response is conserved in related gram-positive bacteria but is missing in strictly anaerobic or in some facultatively anaerobic gram-positive bacteria. It covers functions from nonspecific and multiple stress resistance to the control of virulence in pathogenic bacteria. A comprehensive understanding of this crucial stress response is essential not only for bacterial physiology but also for applied microbiology, including pathogenicity and pathogen control.

引用

页码：215 / 236

页数：22

共 87 条

[1] Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis [J].

Alper, S ;

Dufour, A ;

Garsin, DA ;

Duncan, L ;

Losick, R .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 260 (02) :165-177

[2] BACILLUS-SUBTILIS SIGMA-B IS REGULATED BY A BINDING-PROTEIN (RSBW) THAT BLOCKS ITS ASSOCIATION WITH CORE RNA-POLYMERASE [J].

BENSON, AK ;

HALDENWANG, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2330-2334

[3] THE SIGMA-B-DEPENDENT PROMOTER OF THE BACILLUS-SUBTILIS SIGB OPERON IS INDUCED BY HEAT-SHOCK [J].

BENSON, AK ;

HALDENWANG, WG .

JOURNAL OF BACTERIOLOGY, 1993, 175 (07) :1929-1935

[4] Specific and general stress proteins in Bacillus subtilis - A two-dimensional protein electrophoresis study [J].

Bernhardt, J ;

Volker, U ;

Volker, A ;

Antelmann, H ;

Schmid, R ;

Mach, H ;

Hecker, M .

MICROBIOLOGY-UK, 1997, 143 :999-1017

[5] Microarray-based analysis of the Staphylococcus aureus σB regulon [J].

Bischoff, M ;

Dunman, P ;

Kormanec, J ;

Macapagal, D ;

Murphy, E ;

Mounts, W ;

Berger-Bächi, B ;

Projan, S .

JOURNAL OF BACTERIOLOGY, 2004, 186 (13) :4085-4099

[6] Teicoplanin stress-selected mutations increasing σB activity in Staphylococcus aureus [J].

Bischoff, M ;

Berger-Bächi, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (06) :1714-1720

[7] TRANSCRIPTION FACTOR-SIGMA-B OF BACILLUS-SUBTILIS CONTROLS A LARGE STATIONARY-PHASE REGULON [J].

BOYLAN, SA ;

REDFIELD, AR ;

PRICE, CW .

JOURNAL OF BACTERIOLOGY, 1993, 175 (13) :3957-3963

[8] STRESS-INDUCED ACTIVATION OF THE SIGMA(B) TRANSCRIPTION FACTOR OF BACILLUS-SUBTILIS [J].

BOYLAN, SA ;

REDFIELD, AR ;

BRODY, MS ;

PRICE, CW .

JOURNAL OF BACTERIOLOGY, 1993, 175 (24) :7931-7937

[9] Chill induction of the SigB-dependent general stress response in Bacillus subtilis and its contribution to low-temperature adaptation [J].

Brigulla, M ;

Hoffmann, T ;

Krisp, A ;

Völker, A ;

Bremer, E ;

Völker, U .

JOURNAL OF BACTERIOLOGY, 2003, 185 (15) :4305-4314

[10] Catalytic function of an α/β hydrolase is required for energy stress activation of the σB transcription factor in Bacillus subtilis [J].

Brody, MS ;

Vijay, K ;

Price, CW .

JOURNAL OF BACTERIOLOGY, 2001, 183 (21) :6422-6428

← 1 2 3 4 5 6 7 8 9 →