SigB-dependent general stress response in Bacillus subtilis and related gram-positive bacteria

被引：356

作者：

Hecker, Michael ^{[1
]}

Pane-Farre, Jan

Voelker, Uwe

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Mikrobiol, D-17489 Greifswald, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Interfakultares Genet & Funktionalle Genomforschu, D-17489 Greifswald, Germany

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2007年 / 61卷

关键词：

low G plus C gram-positive bacteria; vegetative dormancy; multiple stress resistance; virulence; pathogenicity;

D O I：

10.1146/annurev.micro.61.080706.093445

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One of the strongest and most noticeable responses of Bacillus subtilis cells to a range of stress and starvation stimuli is the dramatic induction of about 150 SigB-dependent general stress genes. The activity of SigB itself is tightly regulated by a complex signal transduction cascade with at least three main signaling pathways that respond to environmental stress, energy depletion, or low temperature. The SigB-dependent response is conserved in related gram-positive bacteria but is missing in strictly anaerobic or in some facultatively anaerobic gram-positive bacteria. It covers functions from nonspecific and multiple stress resistance to the control of virulence in pathogenic bacteria. A comprehensive understanding of this crucial stress response is essential not only for bacterial physiology but also for applied microbiology, including pathogenicity and pathogen control.

引用

页码：215 / 236

页数：22

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