Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

被引：484

作者：

Warshel, A ^{[1
]}

机构：

[1] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1998年 / 273卷 / 42期

关键词：

D O I：

10.1074/jbc.273.42.27035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：27035 / 27038

页数：4

共 65 条

[51] A RELATIONSHIP BETWEEN PROTEIN STABILITY AND PROTEIN FUNCTION [J].

SHOICHET, BK ;

BAASE, WA ;

KUROKI, R ;

MATTHEWS, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :452-456

[52] MECHANISMS OF HYDROLYSIS OF GLYCOSIDES AND THEIR REVELANCE TO ENZYME-CATALYSED REACTIONS [J].

VERNON, CA .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1967, 167 (1009) :389-+

[53] THEORETICAL STUDIES OF ENZYMIC REACTIONS - DIELECTRIC, ELECTROSTATIC AND STERIC STABILIZATION OF CARBONIUM-ION IN REACTION OF LYSOZYME [J].

WARSHEL, A ;

LEVITT, M .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 103 (02) :227-249

[54] DYNAMICS OF ENZYMATIC-REACTIONS [J].

WARSHEL, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (02) :444-448

[55] HOW DO SERINE PROTEASES REALLY WORK [J].

WARSHEL, A ;

NARAYSZABO, G ;

SUSSMAN, F ;

HWANG, JK .

BIOCHEMISTRY, 1989, 28 (09) :3629-3637

[56] ENZYMES WORK BY SOLVATION SUBSTITUTION RATHER THAN BY DESOLVATION [J].

WARSHEL, A ;

AQVIST, J ;

CREIGHTON, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5820-5824

[57] EVALUATION OF CATALYTIC FREE-ENERGIES IN GENETICALLY MODIFIED PROTEINS [J].

WARSHEL, A ;

SUSSMAN, F ;

HWANG, JK .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 201 (01) :139-159

[58] ENERGETICS OF ENZYME CATALYSIS [J].

WARSHEL, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (11) :5250-5254

[59] Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds [J].

Warshel, A ;

Papazyan, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13665-13670

[60] ON LOW-BARRIER HYDROGEN-BONDS AND ENZYME CATALYSIS [J].

WARSHEL, A ;

PAPAZYAN, A ;

KOLLMAN, PA .

SCIENCE, 1995, 269 (5220) :102-104

← 1 2 3 4 5 6 7 →