Biology and pathogenesis of chikungunya virus

被引：532

作者：

Schwartz, Olivier ^{[1
]}

Albert, Matthew L. ^{[1
]}

机构：

[1] Inst Pasteur, F-75724 Paris 15, France

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 07期

关键词：

SEMLIKI-FOREST-VIRUS; ROSS-RIVER-VIRUS; AEDES-ALBOPICTUS DIPTERA; REUNION-ISLAND OUTBREAK; TOLL-LIKE RECEPTOR-3; DENDRITIC CELLS; INDIAN-OCEAN; INTERFERON-PRODUCTION; FUSION PROTEIN; ALPHAVIRUS REPLICATION;

D O I：

10.1038/nrmicro2368

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region. Although many alphaviruses have been well studied, little was known about the biology and pathogenesis of CHIKV at the time of the 2005 outbreak. Over the past 5 years there has been a multidisciplinary effort aimed at deciphering the clinical, physiopathological, immunological and virological features of CHIKV infection. This Review highlights some of the most recent advances in our understanding of the biology of CHIKV and its interactions with the host.

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收藏

页码：491 / 500

页数：10

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