Application of the evans aziridination procedure to 2-substituted acrylates and cinnamates:: An expedient route to α-substituted α- and β-amino acids

被引：52

作者：

Dauban, P ^{[1
]}

Dodd, RH ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(98)01132-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of the title compounds with Phl=NSO2Ar (Ar = p-tolyl or p-nitrophenyl) in the presence of catalytic copper (II) triflate in acetonitrile gave the corresponding 2 and/or 3-substituted aziridine-2-carboxylates in generally; good yields. The latter, on reaction with nucleophiles, gave alpha-substituted alpha- or beta-amino acids depending on the pattern of substitution on the aziridine ring. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5739 / 5742

页数：4

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