Lipophilic peptides for gene delivery

被引：42

作者：

Prata, Carla A. H. ^{[1
]}

Zhang, Xiao-Xiang ^{[1
]}

Luo, Dan ^{[2
]}

McIntosh, Thomas J. ^{[3
]}

Barthelemy, Philippe ^{[4
]}

Grinstaff, Mark W. ^{[1
]}

机构：

[1] Boston Univ, Dept Biochem Engn & Chem, Boston, MA 02215 USA

[2] Cornell Univ, Dept Biol & Rnvironm Engn, Ithaca, NY 14853 USA

[3] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[4] Univ Victor Segalen, INSERM U869, F-33076 Bordeaux, France

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1021/bc700451b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA transfections are widely performed in research laboratories and in vivo gene delivery holds the promise for curing many diseases. The synthetic carriers or vectors for DNA are typically cationic lipids. However, in biology, the recognition of nucleic acids by proteins involves both electrostatic and stacking contributions. As such we have prepared a series of new lipophilic peptide vectors that possess lysine and tryptophan amino acids for evaluation. These lipophilic peptides show minimal cytotoxicity and enhanced in vitro gene transfection activity.

引用

页码：418 / 420

页数：3

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