Solid-phase synthesis of 2,3-disubstituted indoles:: Discovery of a novel, high-affinity, selective h5-HT2A antagonist

被引：48

作者：

Smith, AL ^{[1
]}

Stevenson, GI ^{[1
]}

Lewis, S ^{[1
]}

Patel, S ^{[1
]}

Castro, JL ^{[1
]}

机构：

[1] Merck Sharp & Dohme Res Labs, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(00)00558-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The application of a novel solid-phase synthesis of 2,3-disubstituted indoles utilizing a carbamate indole linker is described resulting in the identification of the novel, high-affinity, selective h5-HT2A antagonist 19. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2693 / 2696

页数：4

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